How is Prime Editing Different from Other Gene Editing Techniques?
Prime editing offers several advantages over other gene editing technologies such as CRISPR-Cas9 and TALENs. Traditional CRISPR-Cas9 creates double-stranded breaks that are repaired by the cell’s natural repair mechanisms, which can introduce errors. In contrast, prime editing makes precise changes directly at the target site, minimizing off-target effects and unwanted mutations. This precision is particularly crucial in cancer research where even small errors can lead to significant consequences.
