Given its pivotal role in DNA repair, mutations or dysregulation of RAD50 can lead to genomic instability, a hallmark of cancer. Defective RAD50 function impairs the cell's ability to repair DNA damage efficiently, thereby increasing the likelihood of mutations that can drive tumorigenesis. Additionally, upregulation or overexpression of RAD50 has been observed in several types of cancers, suggesting its role in cancer progression and resistance to therapy.
