Which Cancers are Associated with RAD50 Mutations?
Mutations in RAD50 have been identified in various cancers, including breast cancer, colorectal cancer, and leukemia. These mutations often lead to a compromised DNA damage response, which can facilitate the accumulation of additional genetic alterations that promote cancer development. Additionally, RAD50 mutations have been implicated in hereditary cancer syndromes, such as Nijmegen Breakage Syndrome, which is characterized by an increased cancer risk.
