Allele specific copy number analysis is a technique used to quantify the number of copies of each allele at a given locus in the genome. Unlike traditional CNV analysis, which only provides the total number of copies, allele-specific analysis discriminates between the maternal and paternal alleles. This distinction is especially important in cancer, where allelic imbalances such as loss of heterozygosity (LOH) and copy-neutral LOH can have significant implications for tumorigenesis and treatment response.
