Scalp cooling is administered using either gel caps or machine-based systems. Gel caps are typically pre-cooled in a freezer and need to be changed every 30-45 minutes. Machine-based systems, on the other hand, circulate a coolant through a cap, maintaining a constant temperature throughout the treatment session. The cooling process usually starts 30 minutes before chemotherapy and continues for 90 minutes to several hours after the session, depending on the drug regimen.