Serological tests are used to detect the presence of tumor markers in the blood. These markers are substances that are produced by cancer cells or by the body in response to cancer. Some commonly known tumor markers include CA-125 for ovarian cancer, PSA (Prostate-Specific Antigen) for prostate cancer, and CEA (Carcinoembryonic Antigen) for colorectal cancer. Elevated levels of these markers can aid in the early detection and diagnosis of cancer.