Telomerase activity is primarily regulated at the transcriptional level of its catalytic subunit, hTERT (human telomerase reverse transcriptase). Various factors, including genetic mutations, epigenetic changes, and alternative splicing, can influence hTERT expression. Additionally, certain signaling pathways, such as the Wnt/β-catenin and PI3K/AKT pathways, are known to upregulate hTERT transcription.
