How is the Expression of Bcl-2 Family Proteins Regulated?
The expression of Bcl-2 family proteins is tightly regulated by various cellular signals and transcription factors. For example, the tumor suppressor protein p53 can induce the expression of pro-apoptotic members like Bax. On the other hand, survival signals such as those from growth factors can upregulate anti-apoptotic proteins via pathways like PI3K/AKT.
