In cancer, the balance between pro-apoptotic and anti-apoptotic Bcl-2 family proteins is often disrupted, leading to uncontrolled cell survival. Overexpression of anti-apoptotic proteins like Bcl-2 and Bcl-xL is a common feature in many cancers and contributes to chemotherapy resistance. For instance, high levels of Bcl-2 are frequently observed in B-cell lymphomas, chronic lymphocytic leukemia, and other malignancies.
