Preparing for upfront payments involves several steps: 1. Understand Your Treatment Plan: Discuss with your healthcare provider to get a clear idea of the costs involved. 2. Review Your Insurance Coverage: Check what your insurance plan covers and what out-of-pocket expenses you may incur. 3. Explore Financial Assistance: Look into grants, non-profit organizations, and government programs that can help with costs. 4. Create a Budget: Plan your finances to accommodate the upfront payments without compromising other essential expenses.