BLT humanized mice, or Bone Marrow-Liver-Thymus (BLT) mice, are a type of humanized mouse model that has been engrafted with human hematopoietic stem cells (HSCs) as well as human liver and thymus tissues. This model has been extensively used in the field of cancer research for its ability to closely replicate the human immune system and tumor microenvironment. These mice are instrumental in studying human-specific diseases, including various types of cancer.