What are Common Epigenetic Modifications in Cancer?
Several epigenetic modifications are commonly observed in cancer, including:
DNA Methylation: The addition of methyl groups to the DNA molecule, particularly at CpG islands, which often leads to gene silencing. Histone Modification: Chemical changes to histone proteins, such as acetylation, methylation, phosphorylation, and ubiquitination, which can impact chromatin structure and gene expression. Non-coding RNAs: Small RNA molecules, such as microRNAs and long non-coding RNAs, that can regulate gene expression post-transcriptionally.
