- Kinases: Enzymes like EGFR, HER2, and BRAF are often mutated in cancers and can be targeted by small molecule inhibitors. - Growth Factor Receptors: Targets such as VEGF and PDGF are involved in angiogenesis and can be inhibited to starve tumors of blood supply. - Checkpoint Proteins: Proteins like PD-1 and CTLA-4 help cancer cells evade the immune system. Inhibitors such as checkpoint inhibitors can restore immune function.
