What Are the Challenges in Identifying Therapeutic Targets?
Identifying therapeutic targets comes with several challenges:
- Heterogeneity: Cancer is highly heterogeneous, with significant genetic and phenotypic variability between patients, and even within a single tumor. - Drug Resistance: Cancer cells can develop resistance to therapies, making it crucial to identify targets involved in resistance mechanisms. - Toxicity: Targeting molecules that are also essential for normal cell function can lead to significant side effects.
