What Are Common Types of Genomic Alterations in Cancer?
Several types of genomic alterations can be found in cancer genomes:
1. Point Mutations: Single nucleotide changes in the DNA sequence. 2. Insertions and Deletions (Indels): Small additions or losses of DNA bases. 3. Copy Number Variations (CNVs): Changes in the number of copies of a particular gene. 4. Structural Variations: Large-scale alterations in chromosome structure, such as translocations and inversions. 5. Epigenetic Changes: Modifications in gene expression without altering the DNA sequence, often involving DNA methylation and histone modification.
