The histological grade of a tumor refers to how much the cancer cells resemble normal cells. Low-grade tumors have cells that look similar to normal cells and tend to grow slowly, whereas high-grade tumors have cells that look very different and tend to grow rapidly. Staging, on the other hand, describes the extent of cancer spread. It ranges from Stage I (localized) to Stage IV (metastasized). Both grading and staging are crucial for determining the appropriate treatment strategy.