homologous recombination

What are Key Proteins Involved in Homologous Recombination?

Several key proteins play crucial roles in HR, including BRCA1, BRCA2, RAD51, and ATM. BRCA1 and BRCA2 are tumor suppressor genes whose mutations are strongly associated with increased risks of breast, ovarian, and other cancers. These proteins facilitate the recruitment of RAD51 to DNA damage sites, which is critical for strand invasion and exchange during HR.

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