What are the Clinical Implications of Homologous Recombination Deficiency?
Homologous recombination deficiency (HRD) provides both prognostic and therapeutic insights. HRD is often associated with better responses to certain chemotherapies and PARP inhibitors. Genetic testing for HR-related gene mutations can guide personalized treatment strategies. For example, patients with BRCA mutations may benefit from targeted therapies such as PARP inhibitors or platinum-based chemotherapies.
