Methylated MGMT promoters refer to the addition of methyl groups to the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene. This process, known as DNA methylation, typically occurs at cytosine-phosphate-guanine (CpG) islands and leads to the suppression of the gene's expression. MGMT plays a crucial role in the DNA repair mechanism by removing alkyl groups from the O6 position of guanine, thereby preventing DNA mutations that can lead to cancer.
