What Are the Challenges in Developing G6PD Inhibitors?
Despite their potential, developing G6PD inhibitors for clinical use poses several challenges:
Off-Target Effects: Ensuring specificity to avoid affecting normal cells is crucial to minimize potential side effects. Genetic Variability: Variants of the G6PD gene exist in the human population, which might affect individuals' responses to the inhibitors. Compensatory Pathways: Cancer cells might activate alternative pathways to bypass the inhibited PPP, necessitating combination strategies.
