What Are the Mechanisms Behind FGF-Mediated Tumorigenesis?
FGFs contribute to tumorigenesis through several mechanisms:
1. Cell Proliferation: FGF signaling promotes the transition from the G1 to S phase of the cell cycle. 2. Angiogenesis: FGFs stimulate the formation of new blood vessels, providing tumors with oxygen and nutrients. 3. Cell Survival: By activating anti-apoptotic pathways, FGFs help cancer cells evade programmed cell death. 4. Migration and Invasion: FGFs enhance the motility and invasiveness of cancer cells, facilitating metastasis.
