What Types of Cancer Are Associated with Abnormal FGF Signaling?
Several cancers have been linked to dysregulated FGF/FGFR signaling, including:
- Breast Cancer: Overexpression of FGF1 and FGF2 is common. - Lung Cancer: FGFR1 amplification is frequently observed. - Bladder Cancer: Mutations in FGFR3 are prevalent. - Prostate Cancer: Increased FGF8 levels are typical. - Gastric Cancer: FGFR2 amplification is notable.