How Can FGF Signaling Be Targeted in Cancer Therapy?
Given its pivotal role in cancer, FGF signaling represents a viable target for therapeutic intervention. Strategies include:
- FGFR Inhibitors: Small molecule inhibitors like Erdafitinib and Pemigatinib have shown promise in treating cancers with FGFR alterations. - Monoclonal Antibodies: Targeting FGFs or FGFRs with monoclonal antibodies can disrupt ligand-receptor interactions. - Ligand Traps: Soluble FGFRs or engineered proteins can sequester FGFs, preventing them from binding to cell surface receptors.
