Despite its importance, preclinical research faces several challenges:
1. Translational Gap: Results from preclinical studies do not always translate to humans due to differences in biology between animals and humans. This gap can lead to failures in subsequent clinical trials.
2. Ethical Considerations: The use of animals in research raises ethical concerns. Researchers must adhere to strict guidelines and regulations to ensure humane treatment of animals.
3. Complexity of Cancer: Cancer is a highly heterogeneous disease with various subtypes and genetic mutations. This complexity makes it difficult to develop one-size-fits-all treatments and necessitates personalized approaches.
