Despite their potential, there are several challenges in the use of RNA markers in cancer:
- Heterogeneity: Cancer is a highly heterogeneous disease, and the expression of RNA markers can vary widely between different patients and even within different regions of the same tumor. - Stability: RNA molecules are generally less stable than DNA, making their detection and analysis more challenging. - Standardization: There is a lack of standardized protocols for the collection, processing, and analysis of RNA samples, which can lead to variability in results.
