What Are Some Common Genes Associated with Inherited Cancer Risk?
There are several genes commonly associated with an increased risk of cancer when mutated:
1. BRCA1 and BRCA2: Linked to breast and ovarian cancers. 2. TP53: Associated with Li-Fraumeni syndrome, which increases the risk of various cancers. 3. MLH1, MSH2, MSH6, and PMS2: Related to Lynch syndrome, which increases the risk of colorectal cancer. 4. APC: Causes familial adenomatous polyposis and increases colorectal cancer risk. 5. PTEN: Associated with Cowden syndrome, which increases the risk of breast, thyroid, and endometrial cancers.
