Some of the most common genetic mutations in cancer include mutations in the TP53 gene, which codes for the p53 protein that regulates the cell cycle, and mutations in the BRCA1 and BRCA2 genes, which are involved in DNA repair. Other significant mutations include those in the KRAS gene, which is often mutated in pancreatic, colorectal, and lung cancers, and the PIK3CA gene, frequently mutated in breast cancer.
