Several well-known heritable cancer syndromes are associated with specific genetic mutations. For instance:
- Lynch Syndrome: Caused by mutations in genes responsible for DNA mismatch repair, it increases the risk of colorectal cancer and other cancers. - Li-Fraumeni Syndrome: Associated with mutations in the TP53 gene, it predisposes individuals to a wide array of cancers, including sarcomas, breast cancer, and brain tumors. - Familial Adenomatous Polyposis (FAP): Caused by mutations in the APC gene, it leads to the development of multiple colorectal polyps and a high risk of colorectal cancer.
