What are Some Common Therapeutic Targets in Cancer?
Several well-known therapeutic targets have been identified in various types of cancer:
HER2: Overexpressed in certain breast cancers, targeted by drugs like trastuzumab. EGFR: Mutations in this receptor are common in non-small cell lung cancer, targeted by drugs like gefitinib and erlotinib. BRAF: Mutations, particularly the V600E mutation, are found in melanoma and targeted by drugs like vemurafenib. PD-1/PD-L1: Immune checkpoint proteins targeted by immune checkpoint inhibitors such as pembrolizumab and nivolumab. ALK: Rearrangements and mutations in this gene are found in non-small cell lung cancer, targeted by drugs like crizotinib.
