therapeutic target identification:

What Challenges Exist in Target Identification?

Despite advances in technology and research, several challenges remain in therapeutic target identification:
Heterogeneity: Cancer is highly heterogeneous, both within a single tumor and between patients, making it difficult to identify universal targets.
Resistance: Cancer cells can develop resistance to targeted therapies through various mechanisms, including secondary mutations and activation of alternative pathways.
Complexity of Signaling Pathways: Cancer involves multiple, often redundant signaling pathways, complicating the identification of key targets.
Off-Target Effects: Drugs designed to target specific molecules can sometimes affect other proteins, leading to unintended side effects.

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