atp binding site

What Are Some Examples of ATP Binding Site Inhibitors in Cancer Therapy?

Several ATP binding site inhibitors have been approved for clinical use and are being studied for their efficacy in various cancers:
1. Imatinib: Targets the ATP binding site of BCR-ABL in chronic myeloid leukemia.
2. Erlotinib: Inhibits the ATP binding site of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer.
3. Sunitinib: A multi-targeted receptor tyrosine kinase inhibitor used in renal cell carcinoma and gastrointestinal stromal tumors.

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