In cancer cells, proteins involved in cell growth, division, and survival are often dysregulated. Many of these proteins rely on ATP binding and hydrolysis to function. Targeting the ATP binding site can inhibit these proteins' activity, thereby restricting cancer cell proliferation and survival. For instance, kinases, which play a vital role in signal transduction pathways, have ATP binding sites that are essential for their activity. Inhibiting these sites can disrupt aberrant signaling pathways in cancer cells.
