What are Some Examples of Dimeric Protein Complexes in Cancer?
Several dimeric protein complexes are implicated in cancer:
1. [HER2/neu](): This is a receptor tyrosine kinase that forms homodimers or heterodimers with other members of the HER family. Overexpression of HER2 is commonly seen in breast cancer. 2. [p53](): Often referred to as the "guardian of the genome," p53 functions as a homotetramer (a complex of four subunits, essentially two dimers). Mutations in p53 are found in about 50% of human cancers. 3. [NF-κB](): This transcription factor forms dimers that regulate the expression of genes involved in immune response and cell survival. Aberrant NF-κB activity is linked to various cancers.
