What Are Some Examples of Gene-Gene Interactions in Cancer?
One well-known example is the interaction between the BRCA1 gene and the PALB2 gene. Mutations in BRCA1 are linked to a higher risk of breast and ovarian cancers. However, the presence of mutations in PALB2, a gene that interacts with BRCA1 in DNA repair, can further increase this risk. Another example is the interaction between the KRAS and PIK3CA genes in colorectal cancer, which can influence the effectiveness of certain targeted therapies.
