What are Some Examples of Genetic Syndromes Associated with Cancer?
Several genetic syndromes are associated with an increased risk of cancer due to inherited mutations. Some examples include:
- Lynch syndrome: Caused by mutations in DNA mismatch repair genes, leading to a higher risk of colorectal, endometrial, and other cancers. - Li-Fraumeni syndrome: Caused by mutations in the TP53 gene, resulting in a predisposition to various cancers, including sarcomas, breast cancer, and brain tumors. - Familial adenomatous polyposis: Caused by mutations in the APC gene, leading to the development of numerous polyps in the colon and rectum, which can progress to colorectal cancer if untreated.
