Several agents have been investigated for intratumoral administration:
Oncolytic Viruses: Viruses that selectively infect and kill cancer cells, such as T-VEC for melanoma. Immunomodulators: Agents like interleukin-2 (IL-2) or granulocyte-macrophage colony-stimulating factor (GM-CSF) that stimulate the immune system. Chemotherapeutic Agents: Drugs like doxorubicin or paclitaxel can be directly injected to maximize local concentration. Gene Therapy Vectors: Delivery of genetic material to correct or target tumor-specific mutations.
