What are Some Key Findings from Cancer Transcriptomics Studies?
Several significant findings have emerged from cancer transcriptomics:
Oncogenes and Tumor Suppressors: Identification of key oncogenes (e.g., MYC, KRAS) and tumor suppressor genes (e.g., TP53) that are dysregulated in various cancers. Gene Fusion Events: Discovery of fusion genes like BCR-ABL in chronic myeloid leukemia, which have become important therapeutic targets. Immune Landscape: Insights into the tumor microenvironment and immune evasion mechanisms, aiding in the development of immunotherapies. Drug Resistance Mechanisms: Understanding how cancer cells adapt to evade therapies, leading to the development of combination treatments.
