What Are Some Key Findings from PPI Network Studies in Cancer?
Studies have identified several key proteins, known as hubs, that interact with many other proteins and are crucial for maintaining the integrity of the PPI network. For example, the tumor suppressor p53 and the oncogene MYC are well-known hubs in various cancers. Disruption of these hubs can lead to widespread changes in the network, promoting cancer progression. Additionally, PPI network analysis has revealed potential biomarkers for early detection and prognosis of cancer.
