Several kinases have been identified as key players in cancer, including:
EGFR (Epidermal Growth Factor Receptor): Often overexpressed or mutated in various cancers, leading to increased cell proliferation. HER2 (Human Epidermal Growth Factor Receptor 2): Amplified in certain breast cancers, associated with aggressive disease. BCR-ABL: A fusion kinase resulting from a chromosomal translocation, causative in chronic myeloid leukemia (CML). PI3K (Phosphoinositide 3-Kinase): Frequently mutated in cancers, leading to enhanced cell growth and survival. AKT: A downstream kinase in the PI3K pathway, often hyperactivated in cancer.
