What are the Challenges Associated with Kinase Inhibitors?
Despite their efficacy, kinase inhibitors face several challenges, including:
Drug Resistance: Cancer cells can develop resistance to kinase inhibitors through various mechanisms, such as secondary mutations in the kinase domain or activation of alternative signaling pathways. Toxicity: Some kinase inhibitors can cause off-target effects, leading to toxicity and adverse reactions. Tumor Heterogeneity: Different cells within the same tumor can have varying dependencies on specific kinases, complicating treatment strategies.
