What Are Some Key Proteins Involved in Cancer Pathways?
Certain proteins are pivotal in cancer pathways and are often the focus of research and therapeutic strategies. Some key proteins include:
- p53: Known as the "guardian of the genome," p53 plays a critical role in regulating the cell cycle and inducing apoptosis in response to DNA damage. - HER2: Overexpression of the HER2 protein is associated with aggressive forms of breast cancer. - BCL-2: This protein inhibits apoptosis, allowing cancer cells to survive longer than normal cells. - VEGF: Vascular Endothelial Growth Factor is involved in angiogenesis, the process by which new blood vessels form, supplying nutrients and oxygen to tumors.
