What Are the Challenges in Targeting Proteins for Cancer Therapy?
While targeting proteins for cancer therapy holds great promise, it also presents several challenges. These include:
- Drug resistance: Cancer cells can develop resistance to therapies targeting specific proteins, necessitating the development of combination therapies. - Off-target effects: Drugs may affect proteins in normal cells, leading to adverse side effects. - Tumor heterogeneity: The genetic and protein expression diversity within tumors can complicate the effectiveness of targeted therapies.
