What Are Some Key Signaling Pathways Involved in Cancer?
Several key signaling pathways are frequently altered in cancer:
Ras/MAPK Pathway: Often hyperactivated in cancers, leading to increased cell division. PI3K/Akt Pathway: Promotes cell survival and growth; frequently dysregulated in various cancers. Wnt Pathway: Involved in cell fate determination; its aberrant activation is linked to colorectal cancer. Notch Pathway: Plays a role in cell differentiation; abnormalities can lead to hematological malignancies. Hedgehog Pathway: Important for embryonic development; its dysregulation is associated with basal cell carcinoma.
