What Are the Challenges in Targeting Signaling Pathways?
Despite the promise of targeted therapies, there are several challenges. Cancer cells can develop drug resistance through various mechanisms such as secondary mutations, activation of alternative pathways, or increased efflux of the drug. Additionally, the heterogeneity of tumors means that a single targeted therapy may not be effective for all cancer cells within a tumor. Consequently, combination therapies that target multiple pathways simultaneously are often required.
