What Are Some Notable Success Stories in Cancer Proteomics?
Several studies have successfully utilized proteomic profiling to advance cancer research:
1. HER2 in Breast Cancer: Proteomic analysis identified the overexpression of the HER2 protein in a subset of breast cancers, leading to the development of targeted therapies like trastuzumab (Herceptin). 2. EGFR in Lung Cancer: Proteomic studies revealed mutations and overexpression of the EGFR protein in non-small cell lung cancer, resulting in the development of EGFR inhibitors such as gefitinib and erlotinib. 3. PD-L1 in Immunotherapy: Proteomic profiling has identified PD-L1 as a critical protein in cancer immune evasion, leading to the development of immune checkpoint inhibitors like pembrolizumab and nivolumab.
