TCGA has led to several groundbreaking discoveries, including:
The identification of new cancer subtypes based on genetic and molecular profiles, leading to more precise classification of cancers. The discovery of mutational signatures that are characteristic of specific cancer types and environmental exposures. Insights into the role of the tumor microenvironment and its impact on cancer progression and treatment response. The recognition of the importance of epigenetic changes in cancer, such as DNA methylation and histone modifications.
