What are the Challenges and Limitations of Anti-VEGF Therapies?
While anti-VEGF therapies have shown promise, they are not without challenges. One significant issue is the development of resistance. Tumors can adapt by upregulating alternative pro-angiogenic pathways or by increasing the expression of VEGF. Additionally, anti-VEGF therapies can lead to adverse effects such as hypertension, increased risk of bleeding, and impaired wound healing. These limitations highlight the need for further research to enhance the efficacy and safety of these treatments.
