What are the Challenges Associated with Solubilizing Agents?
While solubilizing agents offer significant benefits, they also present several challenges. The addition of solubilizing agents can sometimes lead to toxicity or adverse reactions, as the agents themselves may interact with biological membranes or other cellular components. Furthermore, some solubilizing agents may alter the pharmacokinetics of the drug, leading to unexpected changes in drug distribution and elimination. Regulatory considerations also play a role, as the safety and efficacy of solubilizing agents must be thoroughly evaluated before they are approved for use.
