What are the challenges associated with targeting CENP-E?
While targeting CENP-E holds promise, there are challenges to consider. One major challenge is the potential for toxicity in normal cells, particularly those that rapidly divide, such as bone marrow and gastrointestinal cells. Additionally, cancer cells can develop resistance to CENP-E inhibitors, necessitating combination therapies or the development of next-generation inhibitors. Further research is needed to refine these therapies and minimize adverse effects.
