What is the significance of CENP-E in cancer cells?
Cancer cells often exhibit chromosomal instability (CIN), which can lead to aneuploidyâan abnormal number of chromosomes. CENP-E dysfunction can contribute to CIN by causing improper chromosome segregation. Overexpression or mutations in CENP-E have been observed in various types of cancer, including breast cancer, colorectal cancer, and lung cancer. This suggests that CENP-E may play a role in the progression and development of these malignancies.
